SURVEY AND SUMMARY G-quadruplexes and helicases
نویسندگان
چکیده
Guanine-rich DNA strands can fold in vitro into noncanonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that Gquadruplex structures may act as ‘knots’ within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.
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